Repeated Aconitine Treatment Induced the Remodeling of Mitochondrial Function via AMPK–OPA1–ATP5A1 Pathway

Repeated Aconitine Treatment Induced the Remodeling of Mitochondrial Function via AMPK–OPA1–ATP5A1 Pathway

Aconitine is attracting increasing attention for its unique positive inotropic effect on the cardiovascular system, but underlying molecular mechanisms are still not fully understood. The cardiotonic effect always requires abundant energy supplement, which is mainly related to mitochondrial function...

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Bibliographic Details
Main Authors: Li-Zhen Qiu, Wei Zhou, Lan-Xin Yue, Yi-Hao Wang, Fei-Ran Hao, Peng-Yan Li, Yue Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
aconitine
mitochondrial homeostasis
mitochondrial fusion
OPA1
ATP5A1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.646121/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.646121/full

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