Histidine-Rich Glycoprotein Prevents Septic Lethality through Regulation of Immunothrombosis and Inflammation

Histidine-Rich Glycoprotein Prevents Septic Lethality through Regulation of Immunothrombosis and Inflammation

Sepsis is a major cause of death worldwide. We show that a plasma protein histidine-rich glycoprotein (HRG) was decreased significantly in septic mice with cecal ligation and puncture (CLP) and supplementary treatment of septic mice with exogenous HRG improved survival, with strong inhibition of tig...

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Bibliographic Details
Main Authors: Hidenori Wake, Shuji Mori, Keyue Liu, Yuta Morioka, Kiyoshi Teshigawara, Masakiyo Sakaguchi, Kosuke Kuroda, Yuan Gao, Hideo Takahashi, Aiji Ohtsuka, Tadashi Yoshino, Hiroshi Morimatsu, Masahiro Nishibori
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:EBioMedicine
Subjects:
Histidine-rich glycoprotein
Sepsis
ARDS
Immunothrombosis
Neutrophil
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641630247X

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http://www.sciencedirect.com/science/article/pii/S235239641630247X

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