Pharmacological Inhibition of Focal Adhesion Kinase Attenuates Cardiac Fibrosis in Mice Cardiac Fibroblast and Post-Myocardial-Infarction Models

Pharmacological Inhibition of Focal Adhesion Kinase Attenuates Cardiac Fibrosis in Mice Cardiac Fibroblast and Post-Myocardial-Infarction Models

Background: To investigate the role of focal adhesion kinase (FAK)-mediated signaling in hypoxia-induced cardiac fibroblasts (CFs) differentiation and cardiac fibrosis post-myocardial infarction (MI) on a mice model. Methods: CFs of neonatal C57BL/6 mice were treated under normoxic, hypoxic, or hypo...

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Bibliographic Details
Main Authors: Guang-Pu Fan, Wei Wang, Hui Zhao, Lin Cai, Pei-De Zhang, Zi-He Yang, Jing Zhang, Xu Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Focal adhesion kinase
Cardiac fibroblasts
Cardiac fibrosis
PF-562,271
Myocardial infarction
Online Access:http://www.karger.com/Article/FullText/430373

Internet

http://www.karger.com/Article/FullText/430373

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