Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness

Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness

Abstract Background Metabolic syndrome, an obesity-related condition associated with insulin resistance and low-grade inflammation, leads to diabetes, cardiovascular diseases, cancer, osteoarthritis, and other disorders. Optimal therapy is unknown. The antimalarial drug chloroquine activates the kin...

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Bibliographic Details
Main Authors: Janet B. McGill, Mariko Johnson, Stacy Hurst, William T. Cade, Kevin E. Yarasheski, Richard E. Ostlund, Kenneth B. Schechtman, Babak Razani, Michael B. Kastan, Donald A. McClain, Lisa de las Fuentes, Victor G. Davila-Roman, Daniel S. Ory, Samuel A. Wickline, Clay F. Semenkovich
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Chloroquine
Metabolic syndrome
Carotid intima-media thickness
Insulin sensitivity
Glucose disposal
Atheroma
Online Access:http://link.springer.com/article/10.1186/s13098-019-0456-4

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http://link.springer.com/article/10.1186/s13098-019-0456-4

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