Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness
Abstract Background Metabolic syndrome, an obesity-related condition associated with insulin resistance and low-grade inflammation, leads to diabetes, cardiovascular diseases, cancer, osteoarthritis, and other disorders. Optimal therapy is unknown. The antimalarial drug chloroquine activates the kin...
Main Authors: | Janet B. McGill, Mariko Johnson, Stacy Hurst, William T. Cade, Kevin E. Yarasheski, Richard E. Ostlund, Kenneth B. Schechtman, Babak Razani, Michael B. Kastan, Donald A. McClain, Lisa de las Fuentes, Victor G. Davila-Roman, Daniel S. Ory, Samuel A. Wickline, Clay F. Semenkovich |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-07-01
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Series: | Diabetology & Metabolic Syndrome |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13098-019-0456-4 |
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