FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements[S]

FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements[S]

The bile acid-activated nuclear receptor, FXR (NR1H4), has been implicated in the control of lipid and energy metabolism, but its role in fat tissue, where it is moderately expressed, is not understood. In view of the recent development of FXR-targeting therapeutics for treatment of human metabolic...

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Bibliographic Details
Main Authors: Tim van Zutphen, Johanna H.M. Stroeve, Jiufang Yang, Vincent W. Bloks, Angelika Jurdzinski, Han Roelofsen, Nicolette C.A. Huijkman, Theo H. van Dijk, Roel J. Vonk, Jan van Deursen, Bart Staels, Albert K. Groen, Folkert Kuipers
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Journal of Lipid Research
Subjects:
farnesoid X receptor
hypertrophy
hyperplasia
extracellular matrix
insulin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520323178

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520323178

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