Ligustrazine monomer against cerebral ischemia-reperfusion injury

Ligustrazine (2,3,5,6-tetramethylpyrazine) is a major active ingredient of the Szechwan lovage rhizome and is extensively used in treatment of ischemic cerebrovascular disease. The mechanism of action of ligustrazine use against ischemic cerebrovascular diseases remains unclear at present. This stud...

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Bibliographic Details
Main Authors:	Hai-jun Gao, Peng-fei Liu, Pei-wen Li, Zhuo-yan Huang, Feng-bo Yu, Ting Lei, Yong Chen, Ye Cheng, Qing-chun Mu, Hai-yan Huang
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2015-01-01
Series:	Neural Regeneration Research
Subjects:	active zone stability Drosophila neuromuscular junction dephosphorylation Liprin-α Syd-1 PP2A GSK-3ß living scaffolds neural tissue engineering cell transplant biomaterials regeneration neurotrauma neurodegeneration axon pathfinding cell migration injury plasticity neurodegenerative disease brain therapy neuron microglia neural progenitor tissue engineering neuroregeneration repair central nervous system biomaterial regenerative medicine nanotechnology spinal cord injury axonal regeneration exosome extracellular vesicle microRNA microvesicle nerve gap neurite outgrowth peripheral nerve injury Schwann cell stem cell hemodynamic phases cerebral subarachnoid hemorrhage metabolic crises nerve regeneration hypoxic-ischemic brain damage ginsenoside Rg1 neural stem cells cell transplantation cell differentiation cognition nerve reconstruction neural regeneration brain injury neuroimaging functional magnetic resonance imaging regional homogeneity apoplexy subacute ischemia participants healthy volunteers brain activity NSFC grants neuroprotection cerebral ischemia/reperfusion injury lateral intracerebroventricular injection Apelin-13 nerve apoptosis Bcl-2 caspase-3 fractalkine CX3 chemokine receptor 1 neuronal maturation dendrites doublecortin synaptic maturation newborn neurons neurodegenerative diseases Alzheimer′s disease transgenic animal models mice epimedium herb milkvetch root kudzuvine root divalent metal transporter 1 ferroportin 1 microRNA-124 neurogenesis neuronal survival Huntington′s disease SRY-related HMG box transcription factor 9 brain-derived neurotrophic factor peroxisome proliferator-activated receptor gamma coactivator 1-alpha mutant huntingtin Ras/Raf/Erk1/2 signaling pathway apoptosis regulation inhibition neurogenic bladder bibliometric analysis Web of Science database visualization analysis CiteSpace III citation analysis sciatic nerve injury autologous nerve grafting epineurial suturing three-dimensional finite element models load stress displacement facial palsy Bell′s palsy comparison methodological quality fixed effect model acupuncture incomplete recovery randomized controlled trials electroacupuncture thalidomide ankylosing spondylitis adverse reactions peripheral neuropathy;prospective study treatment dose treatment time age sex neurological diseases nerve growth factor meta-analysis adverse effects nerve conduction velocity ligustrazine
Online Access:	http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=5;spage=832;epage=840;aulast=Gao

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=5;spage=832;epage=840;aulast=Gao

Ligustrazine monomer against cerebral ischemia-reperfusion injury

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