Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes

Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes

The synthesis of the subgroups of acetogenins containing non-adjacent bis-THF and non-adjacent THF-THP core units is reviewed. Specifically, total syntheses of gigantecin, 4-deoxygigantecin, cis-sylvaticin, squamostatin-C, squamostatin-D, sylvaticin and mucocin are discussed.

Bibliographic Details
Main Authors: Richard C. D. Brown, Ian B. Spurr
Format: Article
Language:English
Published: MDPI AG 2010-01-01
Series:Molecules
Subjects:
annonaceous acetogenins
non-adjacent bis-THF
tetrahydrofuran
tetrahydropyran
asymmetric synthesis
1,2-diols
epoxides
cytotoxic natural products
anti-tumour
Online Access:http://www.mdpi.com/1420-3049/15/1/460/

Internet

http://www.mdpi.com/1420-3049/15/1/460/

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