Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of Cancer

Chromosomal common fragile sites (CFSs) are specific mammalian genomic regions that show an increased frequency of gaps and breaks when cells are exposed to replication stress in vitro. CFSs are also consistently involved in chromosomal abnormalities in vivo related to cancer. Interestingly, several...

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Main Authors:	Alessandra Drusco, Yuri Pekarsky, Stefan Costinean, Anna Antenucci, Laura Conti, Stefano Volinia, Rami I. Aqeilan, Kay Huebner, Nicola Zanesi
Format:	Article
Language:	English
Published:	Hindawi Limited 2011-01-01
Series:	Journal of Biomedicine and Biotechnology
Online Access:	http://dx.doi.org/10.1155/2011/984505

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spelling	doaj-8855851d670e431aa0faaaf45fa4b0912020-11-25T00:25:27ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512011-01-01201110.1155/2011/984505984505Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of CancerAlessandra Drusco0Yuri Pekarsky1Stefan Costinean2Anna Antenucci3Laura Conti4Stefano Volinia5Rami I. Aqeilan6Kay Huebner7Nicola Zanesi8Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210 , USADepartment of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210 , USADepartment of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210 , USAClinical Pathology, Regina Elena Institute, IFO, 00144 Rome, ItalyClinical Pathology, Regina Elena Institute, IFO, 00144 Rome, ItalyDepartment of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210 , USADepartment of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210 , USADepartment of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210 , USADepartment of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210 , USAChromosomal common fragile sites (CFSs) are specific mammalian genomic regions that show an increased frequency of gaps and breaks when cells are exposed to replication stress in vitro. CFSs are also consistently involved in chromosomal abnormalities in vivo related to cancer. Interestingly, several CFSs contain one or more tumor suppressor genes whose structure and function are often affected by chromosomal fragility. The two most active fragile sites in the human genome are FRA3B and FRA16D where the tumor suppressor genes FHIT and WWOX are located, respectively. The best approach to study tumorigenic effects of altered tumor suppressors located at CFSs in vivo is to generate mouse models in which these genes are inactivated. This paper summarizes our present knowledge on mouse models of cancer generated by knocking out tumor suppressors of CFS.http://dx.doi.org/10.1155/2011/984505
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Alessandra Drusco Yuri Pekarsky Stefan Costinean Anna Antenucci Laura Conti Stefano Volinia Rami I. Aqeilan Kay Huebner Nicola Zanesi
spellingShingle	Alessandra Drusco Yuri Pekarsky Stefan Costinean Anna Antenucci Laura Conti Stefano Volinia Rami I. Aqeilan Kay Huebner Nicola Zanesi Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of Cancer Journal of Biomedicine and Biotechnology
author_facet	Alessandra Drusco Yuri Pekarsky Stefan Costinean Anna Antenucci Laura Conti Stefano Volinia Rami I. Aqeilan Kay Huebner Nicola Zanesi
author_sort	Alessandra Drusco
title	Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of Cancer
title_short	Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of Cancer
title_full	Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of Cancer
title_fullStr	Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of Cancer
title_full_unstemmed	Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of Cancer
title_sort	common fragile site tumor suppressor genes and corresponding mouse models of cancer
publisher	Hindawi Limited
series	Journal of Biomedicine and Biotechnology
issn	1110-7243 1110-7251
publishDate	2011-01-01
description	Chromosomal common fragile sites (CFSs) are specific mammalian genomic regions that show an increased frequency of gaps and breaks when cells are exposed to replication stress in vitro. CFSs are also consistently involved in chromosomal abnormalities in vivo related to cancer. Interestingly, several CFSs contain one or more tumor suppressor genes whose structure and function are often affected by chromosomal fragility. The two most active fragile sites in the human genome are FRA3B and FRA16D where the tumor suppressor genes FHIT and WWOX are located, respectively. The best approach to study tumorigenic effects of altered tumor suppressors located at CFSs in vivo is to generate mouse models in which these genes are inactivated. This paper summarizes our present knowledge on mouse models of cancer generated by knocking out tumor suppressors of CFS.
url	http://dx.doi.org/10.1155/2011/984505
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Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of Cancer

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