Roles of MAPK and spindle assembly checkpoint in spontaneous activation and MIII arrest of rat oocytes.

Rat oocytes are well known to undergo spontaneous activation (SA) after leaving the oviduct, but the SA is abortive with oocytes being arrested in metaphase III (MIII) instead of forming pronuclei. This study was designed to investigate the mechanism causing SA and MIII arrest. Whereas few oocytes c...

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Bibliographic Details
Main Authors: Wei Cui, Jie Zhang, Hua-Yu Lian, Hui-Li Wang, De-Qiang Miao, Chuan-Xin Zhang, Ming-Jiu Luo, Jing-He Tan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22384134/pdf/?tool=EBI