Targeted genomic profiling revealed a unique clinical phenotype in intrahepatic cholangiocarcinoma with fibroblast growth factor receptor rearrangement

Targeted genomic profiling revealed a unique clinical phenotype in intrahepatic cholangiocarcinoma with fibroblast growth factor receptor rearrangement

Genomic aberrations (GAs) in fibroblast growth factor receptors (FGFRs) are involved in the pathogenesis of intrahepatic cholangiocarcinoma (ICC), and clinical trials have shown efficacy of FGFR inhibitors in treating ICC patients with FGFR GAs such as FGFR2 rearrangement. To clarify the FGFRs GA pr...

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Bibliographic Details
Main Authors: Zhongzheng Zhu, Hui Dong, Jianguo Wu, Wei Dong, Xianling Guo, Hua Yu, Juemin Fang, Song Gao, Xuejun Chen, Huangbin Lu, Wenming Cong, Qing Xu
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Translational Oncology
Subjects:
Intrahepatic cholangiocarcinoma
Fibroblast growth factor receptor
Gene rearrangement
Genomic aberration
Target therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321001601

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http://www.sciencedirect.com/science/article/pii/S1936523321001601

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