t(8;21) Acute Myeloid Leukemia as a Paradigm for the Understanding of Leukemogenesis at the Level of Gene Regulation and Chromatin Programming

t(8;21) Acute Myeloid Leukemia as a Paradigm for the Understanding of Leukemogenesis at the Level of Gene Regulation and Chromatin Programming

Acute myeloid leukemia (AML) is a heterogenous disease with multiple sub-types which are defined by different somatic mutations that cause blood cell differentiation to go astray. Mutations occur in genes encoding members of the cellular machinery controlling transcription and chromatin structure, i...

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Bibliographic Details
Main Authors: Sophie Kellaway, Paulynn S. Chin, Farnaz Barneh, Constanze Bonifer, Olaf Heidenreich
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cells
Subjects:
acute myeloid leukemia
t(8
21)
RUNX1/ETO
epigenetic reprogramming
chromatin
Online Access:https://www.mdpi.com/2073-4409/9/12/2681

Internet

https://www.mdpi.com/2073-4409/9/12/2681

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