Drug Solubility Enhancement through the Preparation of Multicomponent Organic Materials: Eutectics of Lovastatin with Carboxylic Acids

Drug Solubility Enhancement through the Preparation of Multicomponent Organic Materials: Eutectics of Lovastatin with Carboxylic Acids

Lovastatin (LOV) is a drug used to treat hypercholesterolemia. Recent studies have identified its antioxidant effects and potential use in the treatment of some types of cancer. However, the low bioavailability related to its poor water solubility limits its use in solid oral dosage forms. Therefore...

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Bibliographic Details
Main Authors: Andrea Mariela Araya-Sibaja, José Roberto Vega-Baudrit, Teodolito Guillén-Girón, Mirtha Navarro-Hoyos, Silvia Lucia Cuffini
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Pharmaceutics
Subjects:
lovastatin
eutectic mixtures
carboxylic acids
multicomponent organic materials
GRAS substances
Online Access:http://www.mdpi.com/1999-4923/11/3/112

Internet

http://www.mdpi.com/1999-4923/11/3/112

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