A potential new mechanism for pregnancy loss: considering the role of LINE-1 retrotransposons in early spontaneous miscarriage

A potential new mechanism for pregnancy loss: considering the role of LINE-1 retrotransposons in early spontaneous miscarriage

Abstract LINE1 retrotransposons are mobile DNA elements that copy and paste themselves into new sites in the genome. To ensure their evolutionary success, heritable new LINE-1 insertions accumulate in cells that can transmit genetic information to the next generation (i.e., germ cells and embryonic...

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Bibliographic Details
Main Authors: Chao Lou, John L. Goodier, Rong Qiang
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Reproductive Biology and Endocrinology
Subjects:
Spontaneous miscarriage
Retrotransposon, LINE-1
De novo insertion
Human embryogenesis
Mutation
Online Access:https://doi.org/10.1186/s12958-020-0564-x

Internet

https://doi.org/10.1186/s12958-020-0564-x

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