ErbB3 Phosphorylation as Central Event in Adaptive Resistance to Targeted Therapy in Metastatic Melanoma: Early Detection in CTCs during Therapy and Insights into Regulation by Autocrine Neuregulin

ErbB3 Phosphorylation as Central Event in Adaptive Resistance to Targeted Therapy in Metastatic Melanoma: Early Detection in CTCs during Therapy and Insights into Regulation by Autocrine Neuregulin

In recent years the introduction of target therapies with BRAF and MEK inhibitors (MAPKi) and of immunotherapy with anti-CTLA-4 and anti-PD-1 monoclonal antibodies have dramatically improved survival of metastatic melanoma patients. Despite these changes drug resistance remains a major hurdle. Sever...

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Bibliographic Details
Main Authors: Ciro Francesco Ruggiero, Debora Malpicci, Luigi Fattore, Gabriele Madonna, Vito Vanella, Domenico Mallardo, Domenico Liguoro, Valentina Salvati, Mariaelena Capone, Barbara Bedogni, Paolo Antonio Ascierto, Rita Mancini, Gennaro Ciliberto
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
melanoma
target therapy
adaptive resistance
erbb3 phosphorylation
ctcs
neuregulin1
Online Access:https://www.mdpi.com/2072-6694/11/10/1425

Internet

https://www.mdpi.com/2072-6694/11/10/1425

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