Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic β-cells

Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic β-cells

Autophagy is indispensable for the proper architecture and flawless functioning of pancreatic β-cells. A growing body of evidence indicates reciprocal communication between autophagic pathways, apoptosis, and intracellular lipids. The way in which elevated levels of free saturated or unsaturated FAs...

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Bibliographic Details
Main Authors: Justyna Janikiewicz, Katarzyna Hanzelka, Anna Dziewulska, Kamil Kozinski, Pawel Dobrzyn, Tytus Bernas, Agnieszka Dobrzyn
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Journal of Lipid Research
Subjects:
apoptosis
cardiolipin
diabetes
fatty acid/desaturases
insulin
pancreas
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520309664

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http://www.sciencedirect.com/science/article/pii/S0022227520309664

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