Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat

Angiotensin-converting enzyme 2 (ACE 2) in the heart including its sex dependency in the hypertensive heart, has not been much studied compared to ACE. In the present study, we used the Dahl salt-sensitive rat exposed to fructose and salt to model a hypertensive phenotype in males, females, and ovar...

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Bibliographic Details
Main Authors: Kirsti Ytrehus, Stian Ludvigsen, Costantino Mancusi, Eva Gerdts, Giovanni de Simone
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Physiology
Subjects:
rat
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.663819/full