Bersavine: A Novel Bisbenzylisoquinoline Alkaloid with Cytotoxic, Antiproliferative and Apoptosis-Inducing Effects on Human Leukemic Cells

Bersavine: A Novel Bisbenzylisoquinoline Alkaloid with Cytotoxic, Antiproliferative and Apoptosis-Inducing Effects on Human Leukemic Cells

Bersavine is the new bisbenzylisoquinoline alkaloid isolated from the <i>Berberis vulgaris</i> L. (Berberidaceae) plant. The results of cytotoxicity screening 48 h post-treatment showed that bersavine considerably inhibits the proliferation and viability of leukemic (Jurkat, MOLT-4), col...

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Bibliographic Details
Main Authors: Darja Koutova, Monika Kulhava, Radim Havelek, Martina Majorosova, Karel Královec, Klara Habartova, Anna Hošťálková, Lubomír Opletal, Lucie Cahlikova, Martina Řezáčová
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
bersavine
antiproliferative activity
cytotoxicity
cell cycle
apoptosis
Online Access:https://www.mdpi.com/1420-3049/25/4/964

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https://www.mdpi.com/1420-3049/25/4/964

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