Delivery of siRNA in vitro and in vivo using PEI-capped porous silicon nanoparticles to silence MRP1 and inhibit proliferation in glioblastoma

Delivery of siRNA in vitro and in vivo using PEI-capped porous silicon nanoparticles to silence MRP1 and inhibit proliferation in glioblastoma

Abstract Background Multidrug resistance-associated protein 1 (MRP1) overexpression plays a major role in chemoresistance in glioblastoma multiforme (GBM) contributing to its notorious deadly nature. Although MRP1-siRNA transfection to GBM in vitro has been shown to sensitise the cells to drug, MRP1...

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Bibliographic Details
Main Authors: Wing Yin Tong, Mohammed Alnakhli, Richa Bhardwaj, Sinoula Apostolou, Sougata Sinha, Cara Fraser, Tim Kuchel, Bryone Kuss, Nicolas H. Voelcker
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Nanobiotechnology
Subjects:
Brain tumour
Gene delivery
Nanoparticles
Multidrug resistance-associated protein
siRNA
Cell proliferation
Online Access:http://link.springer.com/article/10.1186/s12951-018-0365-y

Internet

http://link.springer.com/article/10.1186/s12951-018-0365-y

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