Lupenone Protects Neuroblastoma SH-SY5y Cells Against Methamphetamine-Induced Apoptotic Cell Death via PI3K/Akt/mTOR Signaling Pathway

Lupenone Protects Neuroblastoma SH-SY5y Cells Against Methamphetamine-Induced Apoptotic Cell Death via PI3K/Akt/mTOR Signaling Pathway

Methamphetamine (METH) is an addictive psychostimulant showing neurotoxicity through neuronal apoptosis and the neuro-inflammatory pathway. Lupenone, a lupane triterpenoid, is an isolated compound exhibiting anti-oxidative, anti-inflammation, and anti-diabetic activities. However, whether lupenone p...

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Bibliographic Details
Main Authors: Hyun-Su Lee, Eun-Nam Kim, Gil-Saeng Jeong
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
methamphetamine
neuroblastoma
pi3k
akt
apoptosis
Online Access:https://www.mdpi.com/1422-0067/21/5/1617

Internet

https://www.mdpi.com/1422-0067/21/5/1617

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