Poly-ICLC, a TLR3 Agonist, Induces Transient Innate Immune Responses in Patients With Treated HIV-Infection: A Randomized Double-Blinded Placebo Controlled Trial

Poly-ICLC, a TLR3 Agonist, Induces Transient Innate Immune Responses in Patients With Treated HIV-Infection: A Randomized Double-Blinded Placebo Controlled Trial

Objective: Toll-like receptor-3 agonist Poly-ICLC has been known to activate immune cells and induce HIV replication in pre-clinical experiments. In this study we investigated if Poly-ICLC could be used for disrupting HIV latency while simultaneously enhancing innate immune responses.Design: This wa...

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Bibliographic Details
Main Authors: Mansi Saxena, Rachel L. Sabado, Melissa La Mar, Hiroshi Mohri, Andres M. Salazar, Hanqing Dong, Joel Correa Da Rosa, Martin Markowitz, Nina Bhardwaj, Elizabeth Miller
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
HIV-1
vaccine
adjuvant
poly-ICLC
toll-like receptor ligand
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00725/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00725/full

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