Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor

Small-molecule HIV-1 entry inhibitors are an extremely attractive therapeutic modality. We have previously demonstrated that the entry inhibitor class can be optimized by using computational means to identify and extend the chemotypes available. Here we demonstrate unique and differential effects of...

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Bibliographic Details
Main Authors: Megan E. Meuser, Adel A. Rashad, Gabriel Ozorowski, Alexej Dick, Andrew B. Ward, Simon Cocklin
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
bioisosteres
HIV-1 Env
antiviral
surface plasmon resonance
computer-aided drug design
Online Access:https://www.mdpi.com/1420-3049/24/8/1581

Internet

https://www.mdpi.com/1420-3049/24/8/1581

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