Gemigliptin Inhibits Interleukin-1β–Induced Endothelial-Mesenchymal Transition via Canonical-Bone Morphogenetic Protein Pathway

Gemigliptin Inhibits Interleukin-1β–Induced Endothelial-Mesenchymal Transition via Canonical-Bone Morphogenetic Protein Pathway

Background Endothelial-to-mesenchymal transition (EndMT) contributes to inflammatory conditions inducing conversion of endothelial cells (ECs) into activated fibroblasts, promoting fibrotic diseases. Pro-inflammatory cytokine is the most potent inducer of EndMT. We investigated inhibition of interle...

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Bibliographic Details
Main Authors: Oak-Kee Hong, Seong-Su Lee, Soon Jib Yoo, Min-Kyung Lee, Mee-Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
Format: Article
Language:English
Published: Academya Publishing Co. 2020-06-01
Series:Endocrinology and Metabolism
Subjects:
lc15-0444
dipeptidyl-peptidase iv inhibitors
interleukin-1beta
bone morphogenetic proteins
endothelial-to-mesenchymal transition
Online Access:http://www.e-enm.org/upload/pdf/EnM-2020-35-2-384.pdf

Internet

http://www.e-enm.org/upload/pdf/EnM-2020-35-2-384.pdf

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