Infrequent V617F mutation of the JAK2 gene in myeloid leukemia and its absence in lymphoid malignancies in Japan

Infrequent V617F mutation of the JAK2 gene in myeloid leukemia and its absence in lymphoid malignancies in Japan

A unique mutation of the JAK2 gene, V617F, has recently been identified in polycythemia vera, essential thrombocythemia and myeloid metaplasia with myelofibrosis. To determine the relevance of this mutation in other types of hematological neoplasms in Japan, we performed allele-specific polymerase c...

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Bibliographic Details
Main Authors: Naoki Mori, Kentaro Yoshinaga, Makiko Tada, Yanhua Wang, Masayuki Shiseki, Toshiko Motoji
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2008-01-01
Series:Genetics and Molecular Biology
Subjects:
JAK2 gene
V617F mutation
signal transduction
acute myeloid leukemia
lymphoid malignancies
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000300006

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000300006

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