Monomethyl Auristatin E, a Potent Cytotoxic Payload for Development of Antibody-Drug Conjugates against Breast Cancer

Monomethyl Auristatin E, a Potent Cytotoxic Payload for Development of Antibody-Drug Conjugates against Breast Cancer

<h2>Background: Breast cancer is a heterogeneous disease characterized by differential responses to targeted and chemotherapeutic agents. Antibody-drug conjugates are one of the promising strategies for the treatment of breast cancer. Monomethyl auristatin E (MMAE) is a highly potent microtubu...

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Bibliographic Details
Main Authors: Meghdad Abdollahpour-alitappeh, Amir Amanzadeh, Fatemeh Heidarnejad, Mahdi Habibi-Anbouhi, Majid Lotfinia, Sepand Razavi-vakhshourpour, Saeed Jahandideh, Hamid Najminejad, Saeed Balalaie, Mohsen Abolhassani
Format: Article
Language:English
Published: Shahid Beheshti University of Medical Sciences 2017-06-01
Series:Novelty in Biomedicine
Subjects:
Monomethyl auristatin E, cytotoxicity, Antibody-drug conjugate, MDA-MB-468, MDA-MB-453
Online Access:http://journals.sbmu.ac.ir/nbm/article/view/15523

Internet

http://journals.sbmu.ac.ir/nbm/article/view/15523

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