Longitudinal transcriptomic analysis of altered pathways in a CHMP2Bintron5-based model of ALS-FTD

Longitudinal transcriptomic analysis of altered pathways in a CHMP2Bintron5-based model of ALS-FTD

Amyotrophic lateral sclerosis and frontotemporal dementia are two neurodegenerative diseases with currently no cure. These two diseases share a clinical continuum with overlapping genetic causes. Mutations in the CHMP2B gene are found in patients with ALS, FTD and ALS-FTD. To highlight deregulated m...

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Bibliographic Details
Main Authors: Robin Waegaert, Sylvie Dirrig-Grosch, Florian Parisot, Céline Keime, Alexandre Henriques, Jean-Philippe Loeffler, Frédérique René
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Frontotemporal dementia
Transcriptomic analysis CHMP2Bintron5
SOD1G86R
Mouse models
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119303857

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http://www.sciencedirect.com/science/article/pii/S0969996119303857

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