Bilirubin inhibits the up-regulation of inducible nitric oxide synthase by scavenging reactive oxygen species generated by the toll-like receptor 4-dependent activation of NADPH oxidase

Bilirubin inhibits the up-regulation of inducible nitric oxide synthase by scavenging reactive oxygen species generated by the toll-like receptor 4-dependent activation of NADPH oxidase

It has been previously shown that bilirubin prevents the up-regulation of inducible nitric oxide synthase (iNOS) in response to LPS. The present study examines whether this effect is exerted through modulation of Toll-Like Receptor-4 (TLR4) signaling. LPS-stimulated iNOS and NADPH oxidase (Nox) acti...

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Bibliographic Details
Main Authors: Gila Idelman, Darcey L.H. Smith, Stephen D. Zucker
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231715000592

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http://www.sciencedirect.com/science/article/pii/S2213231715000592

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