Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough

Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough

Objective Airway sensory nerves involved in the cough reflex are activated by adenosine triphosphate (ATP) agonism of P2X purinoceptor 3 (P2X3) receptors. Transient receptor potential vanilloid 4 (TRPV4) channel activation causes ATP release from airway cells, and it is hypothesised that a TRPV4-ATP...

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Bibliographic Details
Main Authors: Valerie J. Ludbrook, Kate E. Hanrott, James L. Kreindler, Joanna E. Marks-Konczalik, Nick P. Bird, Debbie A. Hewens, Misba Beerahee, David J. Behm, Alyn Morice, Lorcan McGarvey, Sean M. Parker, Surinder S. Birring, Jaclyn Smith
Format: Article
Language:English
Published: European Respiratory Society 2021-08-01
Series:ERJ Open Research
Online Access:http://openres.ersjournals.com/content/7/3/00269-2021.full

Internet

http://openres.ersjournals.com/content/7/3/00269-2021.full

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