Genome-Wide and Phenotypic Evaluation of Stem Cell Progenitors Derived From Gprc5a-Deficient Murine Lung Adenocarcinoma With Somatic Kras Mutations

Genome-Wide and Phenotypic Evaluation of Stem Cell Progenitors Derived From Gprc5a-Deficient Murine Lung Adenocarcinoma With Somatic Kras Mutations

Lung adenocarcinomas (LUADs) with somatic mutations in the KRAS oncogene comprise the most common molecular subtype of lung cancer in smokers and present with overall dismal prognosis and resistance to most therapies. Our group recently demonstrated that tobacco carcinogen-exposed mice with knockout...

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Bibliographic Details
Main Authors: Reem Daouk, Maya Hassane, Hisham F. Bahmad, Ansam Sinjab, Junya Fujimoto, Wassim Abou-Kheir, Humam Kadara
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Oncology
Subjects:
lung adenocarcinoma
Kras
stem cell progenitors
Gprc5a
lung cancer pathogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00207/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00207/full

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