CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis

CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis

Abstract Background CDK5, an atypical member of the CDK family, play a significant role in the tumorigenesis of multiple organ, but CDK5 and its substrates in genesis and development of HCC is still unclear. Methods Expression of CDK5 in HCC tumor and paired adjacent noncancerous tissues from 90 pat...

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Bibliographic Details
Main Authors: Fuqiang Wang, Wenxing Zhao, Yuehong Gao, Jiechao Zhou, Huifang Li, Guanyun Zhang, Dong Guo, Chengrong Xie, Jie Li, Zhenyu Yin, Jie Zhang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cyclin-dependent kinase 5
Hepatocellular carcinoma
Target protein for Xklp2
Tamoxifen
Online Access:http://link.springer.com/article/10.1186/s13046-019-1297-6

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http://link.springer.com/article/10.1186/s13046-019-1297-6

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