Evaluation by simulation of clinical trial designs for evaluation of treatment during a viral haemorrhagic fever outbreak

Abstract Background Viral haemorrhagic fevers are characterized by irregular outbreaks with high mortality rate. Difficulties arise when implementing therapeutic trials in this context. The outbreak duration is hard to predict and can be short compared to delays of trial launch and number of subject...

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Bibliographic Details
Main Authors: Pauline Manchon, Drifa Belhadi, France Mentré, Cédric Laouénan
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:https://doi.org/10.1186/s12874-021-01287-w