Dopamine D2 antagonist-induced striatal Nur77 expression requires activation of mGlu5 receptors by cortical afferents

Dopamine D2 antagonist-induced striatal Nur77 expression requires activation of mGlu5 receptors by cortical afferents

Dopamine D2 receptor antagonists modulate gene transcription in the striatum. However, the molecular mechanism underlying this effect remains elusive. Here we used the expression of Nur77, a transcription factor of the orphan nuclear receptor family, as readout to explore the role of dopamine, gluta...

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Bibliographic Details
Main Authors: Jérôme eMaheux, Michel eSt-Hilaire, David eVoyer, Emanuele eTirotta, Emiliana eBorrelli, Claude eRouillard, Pierre-Paul eRompré, Daniel eLévesque
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Pharmacology
Subjects:
glutamate receptors
neuroleptics
Striatum
transcription factor
adenosine receptors
gene transcription
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00153/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00153/full

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