Alkyl halides as both hydride and alkyl sources in catalytic regioselective reductive olefin hydroalkylation

Methods that regioselectively install a functionalized alkyl unit at the 2-position of a terminal unactivated C=C bond are scarce. Here, the authors report a Markovnikov-selective hydroalkylation of unactivated amide-tethered alkenes catalyzed by nickel in conjunction with a stoichiometric reductant...

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Bibliographic Details
Main Authors: Xianxiao Chen, Weidong Rao, Tao Yang, Ming Joo Koh
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19717-6