Rethinking the Combination of Proton Exchanger Inhibitors in Cancer Therapy

Rethinking the Combination of Proton Exchanger Inhibitors in Cancer Therapy

Microenvironmental acidity is becoming a key target for the new age of cancer treatment. In fact, while cancer is characterized by genetic heterogeneity, extracellular acidity is a common phenotype of almost all cancers. To survive and proliferate under acidic conditions, tumor cells up-regulate pro...

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Bibliographic Details
Main Authors: Elisabetta Iessi, Mariantonia Logozzi, Davide Mizzoni, Rossella Di Raimo, Claudiu T. Supuran, Stefano Fais
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Metabolites
Subjects:
acidity
hypoxia
pH
carbonic anhydrases
V-ATPases
proton pump inhibitors
carbonic anhydrase inhibitors
Online Access:https://www.mdpi.com/2218-1989/8/1/2

Internet

https://www.mdpi.com/2218-1989/8/1/2

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