The role of REST and HDAC2 in epigenetic dysregulation of Nav1.5 and nNav1.5 expression in breast cancer

The role of REST and HDAC2 in epigenetic dysregulation of Nav1.5 and nNav1.5 expression in breast cancer

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Abstract Background Increased expression of voltage-gated sodium channels (VGSCs) have been implicated with strong metastatic potential of human breast cancer in vitro and in vivo where the main culprits are cardiac isoform Nav1.5 and its ‘neonatal’ splice variant, nNav1.5. Several factors have been...

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Bibliographic Details
Main Authors: Nur Sabrina Kamarulzaman, Hemaniswarri Dewi Dewadas, Chiuan Yee Leow, Nik Soriani Yaacob, Noor Fatmawati Mokhtar
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Cancer Cell International
Subjects:
Nav1.5
nNav1.5
REST
HDAC2
TSA
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s12935-017-0442-6

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http://link.springer.com/article/10.1186/s12935-017-0442-6

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