Total DNA methylation in the brain in response to decitabine treatment in female rats
Hypomethylating agent decitabine is being used in the treatment of certain types of leukaemia in combination with other anticancer drugs. Aberrant DNA methylation has been suggested to occur in pathological states including depression. Scarce data in male rats suggest antidepressant effects of decit...
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Online Access: | https://doi.org/10.2478/afpuc-2019-0005 |
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doaj-88c23b5b9bd8486b9551f035d80d72ee2021-09-06T19:41:04ZengSciendoEuropean Pharmaceutical Journal2453-67252019-06-016611310.2478/afpuc-2019-0005afpuc-2019-0005Total DNA methylation in the brain in response to decitabine treatment in female ratsBalagova L.0Buzgoova K.1Karailiev P.2Jezova D.3Slovak Academy of Sciences, Biomedical Research Center, Institute of Experimental Endocrinology;Slovak Academy of Sciences, Biomedical Research Center, Institute of Experimental Endocrinology;Slovak Academy of Sciences, Biomedical Research Center, Institute of Experimental Endocrinology;Slovak Academy of Sciences, Biomedical Research Center, Institute of Experimental Endocrinology;Hypomethylating agent decitabine is being used in the treatment of certain types of leukaemia in combination with other anticancer drugs. Aberrant DNA methylation has been suggested to occur in pathological states including depression. Scarce data in male rats suggest antidepressant effects of decitabine. The main aim of our studies is to test the hypothesis that the inhibition of DNA methylation results in antidepressant effects in female rats. Before doing so, we decided to verify the effects of decitabine on DNA methylation in females. The findings demonstrate that the treatment with decitabine at the dose shown previously to inhibit DNA methylation in males, had no effect on total DNA methylation in two brain regions, namely the hippocampus and frontal cortex of female rats. In conclusion, the present study allows us to suggest that the effect of decitabine on DNA methylation in the brain is sex dependent.https://doi.org/10.2478/afpuc-2019-00055-aza-2′-deoxycytidineepigeneticsgender |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Balagova L. Buzgoova K. Karailiev P. Jezova D. |
spellingShingle |
Balagova L. Buzgoova K. Karailiev P. Jezova D. Total DNA methylation in the brain in response to decitabine treatment in female rats European Pharmaceutical Journal 5-aza-2′-deoxycytidine epigenetics gender |
author_facet |
Balagova L. Buzgoova K. Karailiev P. Jezova D. |
author_sort |
Balagova L. |
title |
Total DNA methylation in the brain in response to decitabine treatment in female rats |
title_short |
Total DNA methylation in the brain in response to decitabine treatment in female rats |
title_full |
Total DNA methylation in the brain in response to decitabine treatment in female rats |
title_fullStr |
Total DNA methylation in the brain in response to decitabine treatment in female rats |
title_full_unstemmed |
Total DNA methylation in the brain in response to decitabine treatment in female rats |
title_sort |
total dna methylation in the brain in response to decitabine treatment in female rats |
publisher |
Sciendo |
series |
European Pharmaceutical Journal |
issn |
2453-6725 |
publishDate |
2019-06-01 |
description |
Hypomethylating agent decitabine is being used in the treatment of certain types of leukaemia in combination with other anticancer drugs. Aberrant DNA methylation has been suggested to occur in pathological states including depression. Scarce data in male rats suggest antidepressant effects of decitabine. The main aim of our studies is to test the hypothesis that the inhibition of DNA methylation results in antidepressant effects in female rats. Before doing so, we decided to verify the effects of decitabine on DNA methylation in females. The findings demonstrate that the treatment with decitabine at the dose shown previously to inhibit DNA methylation in males, had no effect on total DNA methylation in two brain regions, namely the hippocampus and frontal cortex of female rats. In conclusion, the present study allows us to suggest that the effect of decitabine on DNA methylation in the brain is sex dependent. |
topic |
5-aza-2′-deoxycytidine epigenetics gender |
url |
https://doi.org/10.2478/afpuc-2019-0005 |
work_keys_str_mv |
AT balagoval totaldnamethylationinthebraininresponsetodecitabinetreatmentinfemalerats AT buzgoovak totaldnamethylationinthebraininresponsetodecitabinetreatmentinfemalerats AT karailievp totaldnamethylationinthebraininresponsetodecitabinetreatmentinfemalerats AT jezovad totaldnamethylationinthebraininresponsetodecitabinetreatmentinfemalerats |
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1717767114991861760 |