Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin

Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin

This study explores the contributions of neutrophils to chemotherapeutic resistance and berberine-regulated cancer cell sensitivity to doxorubicin (DOX). In vitro experiments, continuous DOX treatment led to the shift of HL-60 cells to N2 neutrophils and thus induced chemotherapeutic resistance. The...

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Bibliographic Details
Main Authors: Shuhui Zhang, Lin Zhou, Mengdi Zhang, Yuehua Wang, Mengqi Wang, Jincheng Du, Wenwen Gu, Fuguang Kui, Jiahuan Li, Shengnan Geng, Gangjun Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
berberine
doxorubicin
neutrophil phenotype
carcinogenesis
chemotherapeutic resistance
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01658/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01658/full

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