Cyclic nitroxides inhibit the toxicity of nitric oxide-derived oxidants: mechanisms and implications

Cyclic nitroxides inhibit the toxicity of nitric oxide-derived oxidants: mechanisms and implications

The substantial therapeutic potential of tempol (4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy) and related cyclic nitroxides as antioxidants has stimulated innumerous studies of their reactions with reactive oxygen species. In comparison, reactions of nitroxides with nitric oxide-derived oxidants...

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Bibliographic Details
Main Authors: Ohara Augusto, Daniel F. Trindade, Edlaine Linares, Sandra M. Vaz
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2008-03-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
nitróxidos cíclicos
tempol
antioxidantes
oxidantes derivados do óxido nítrico
inflamação
hepatotoxicidade induzida por acetaminofeno
cyclic nitroxides
antioxidants
nitric oxide-derived oxidants
inflammation
acetaminopheninduced hepatotoxicity
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100013

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100013

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