In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions

In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions

The aim was to evaluate the potential of mucus-permeating nanoparticles for the oral administration of insulin. These nanocarriers, based on the coating of zein nanoparticles with a polymer conjugate containing PEG, displayed a size of 260 nm with a negative surface charge and an insulin payload of...

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Bibliographic Details
Main Authors: Ana L. Martínez-López, Carlos J. González-Navarro, Paula Aranaz, José L. Vizmanos, Juan M. Irache
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Nanoparticles
Oral delivery
Mucus-permeating
Biodistribution
Insulin
Caenorhabditis elegans
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352100068X

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http://www.sciencedirect.com/science/article/pii/S221138352100068X

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