Amlexanox attenuates experimental autoimmune encephalomyelitis by inhibiting dendritic cell maturation and reprogramming effector and regulatory T cell responses

Amlexanox attenuates experimental autoimmune encephalomyelitis by inhibiting dendritic cell maturation and reprogramming effector and regulatory T cell responses

Abstract Background Amlexanox (ALX), a TBK1 inhibitor, can modulate immune responses and has anti-inflammatory properties. To investigate its role in regulating the progression of experimental autoimmune encephalomyelitis (EAE), we studied the effect of ALX on the maturation of dendritic cells (DCs)...

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Bibliographic Details
Main Authors: Mo-Yuan Quan, Xiu-Juan Song, Hui-Jia Liu, Xiao-Hong Deng, Hui-Qing Hou, Li-Ping Chen, Tian-Zhao Ma, Xu Han, Xin-Xin He, Zhen Jia, Li Guo
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Neuroinflammation
Subjects:
Amlexanox
Dendritic cells
TBK1
IRF3
AKT
Experimental autoimmune encephalomyelitis
Online Access:http://link.springer.com/article/10.1186/s12974-019-1438-z

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http://link.springer.com/article/10.1186/s12974-019-1438-z

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