Diversity-Oriented Synthesis of a Library of Substituted Tetrahydropyrones Using Oxidative Carbon-Hydrogen Bond Activation and Click Chemistry

Diversity-Oriented Synthesis of a Library of Substituted Tetrahydropyrones Using Oxidative Carbon-Hydrogen Bond Activation and Click Chemistry

Eighteen (2RS,6RS)-2-(4-methoxyphenyl)-6-(substituted ethyl)dihydro-2H-pyran-4(3H)ones were synthesized via a DDQ-mediated oxidative carbon-hydrogen bond activation reaction. Fourteen of these tetrahydropyrans were substituted with triazoles readily assembled via azide-alkyne click-chemistry reactio...

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Bibliographic Details
Main Authors: Paul E. Floreancig, Lei Liu, Peter Wipf, Matthew G. LaPorte, Ramy Farid, Nilesh Zaware
Format: Article
Language:English
Published: MDPI AG 2011-05-01
Series:Molecules
Subjects:
Tetrahydropyran
C-H activation
click-chemistry
diversity-oriented synthesis
Online Access:http://www.mdpi.com/1420-3049/16/5/3648/

Internet

http://www.mdpi.com/1420-3049/16/5/3648/

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