Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers

Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers

The accumulation and deposition of amyloid beta (Aβ) peptide in extracellular dense plaques in the brain is a key phase in Alzheimer's disease (AD). Small oligomeric forms of Aβ are responsible for the toxicity and the early cognitive impairment observed in patients before the amyloid plaque de...

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Bibliographic Details
Main Authors: Luisa Diomede, Giuseppe Cassata, Fabio Fiordaliso, Monica Salio, Diletta Ami, Antonino Natalello, Silvia Maria Doglia, Ada De Luigi, Mario Salmona
Format: Article
Language:English
Published: Elsevier 2010-11-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
C. elegans
Transgenic
Tetracycline
Amyloid
Amyloid beta-peptide
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002263

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http://www.sciencedirect.com/science/article/pii/S0969996110002263

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