The Recombinant Inhibitor of DNA Binding Id2 Forms Multimeric Structures via the Helix-Loop-Helix Domain and the Nuclear Export Signal

The Recombinant Inhibitor of DNA Binding Id2 Forms Multimeric Structures via the Helix-Loop-Helix Domain and the Nuclear Export Signal

The inhibitor of DNA binding and cell differentiation 2 (Id2) is a helix-loop-helix (HLH) protein that acts as negative dominant regulator of basic-HLH transcription factors during development and in cancer. The structural properties of Id2 have been investigated so far by using synthetic or recombi...

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Bibliographic Details
Main Authors: Cornelia Roschger, Mario Schubert, Christof Regl, Ancuela Andosch, Augusto Marquez, Thomas Berger, Christian G. Huber, Ursula Lütz-Meindl, Chiara Cabrele
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:International Journal of Molecular Sciences
Subjects:
helix-loop-helix domain
intrinsic disorder
protein oligomerization
protein self-assembly
inhibitor of DNA binding
protein fibrils
Online Access:http://www.mdpi.com/1422-0067/19/4/1105

Internet

http://www.mdpi.com/1422-0067/19/4/1105

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