INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling

INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling

Homeostasis at mucosal surfaces requires cross-talk between the environment and barrier epithelial cells. Disruption of barrier function typifies mucosal disease. Here we elucidate a bifunctional role in coordinating this cross-talk for the inflammatory bowel disease risk-gene INAVA. Both activities...

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Bibliographic Details
Main Authors: Phi Luong, Matija Hedl, Jie Yan, Tao Zuo, Tian-Min Fu, Xiaomo Jiang, Jay R Thiagarajah, Steen H Hansen, Cammie F Lesser, Hao Wu, Clara Abraham, Wayne I Lencer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
ARNO
IL-1b
TRAF6
epithelial barrier
actin assembly
inflammatory bowel disease
Online Access:https://elifesciences.org/articles/38539

Internet

https://elifesciences.org/articles/38539

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