CP100356 Hydrochloride, a P-Glycoprotein Inhibitor, Inhibits Lassa Virus Entry: Implication of a Candidate Pan-Mammarenavirus Entry Inhibitor

CP100356 Hydrochloride, a P-Glycoprotein Inhibitor, Inhibits Lassa Virus Entry: Implication of a Candidate Pan-Mammarenavirus Entry Inhibitor

Lassa virus (LASV)—a member of the family <i>Arenaviridae</i>—causes Lassa fever in humans and is endemic in West Africa. Currently, no approved drugs are available. We screened 2480 small compounds for their potential antiviral activity using pseudotyped vesicular stomatitis virus harbo...

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Bibliographic Details
Main Authors: Toru Takenaga, Zihan Zhang, Yukiko Muramoto, Sarah Katharina Fehling, Ai Hirabayashi, Yuki Takamatsu, Junichi Kajikawa, Sho Miyamoto, Masahiro Nakano, Shuzo Urata, Allison Groseth, Thomas Strecker, Takeshi Noda
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Viruses
Subjects:
Lassa virus
lymphocytic choriomeningitis virus
arenavirus
pseudotyped vesicular stomatitis virus
entry inhibitor
Online Access:https://www.mdpi.com/1999-4915/13/9/1763

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https://www.mdpi.com/1999-4915/13/9/1763

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