Inactivation of AMPK Mediates High Phosphate-Induced Extracellular Matrix Accumulation via NOX4/TGFß-1 Signaling in Human Mesangial Cells

Inactivation of AMPK Mediates High Phosphate-Induced Extracellular Matrix Accumulation via NOX4/TGFß-1 Signaling in Human Mesangial Cells

Background/Aims: High phosphate (Pi) levels and extracellular matrix (ECM) accumulation are associated with chronic kidney disease progression. However, how high Pi levels contribute to ECM accumulation in mesangial cells is unknown. The present study investigated the role and mechanism of high Pi l...

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Bibliographic Details
Main Authors: Alexandros Papadimitriou, Elisa B.M.I. Peixoto, Kamila C. Silva, Jacqueline M. Lopes de Faria, José B. Lopes de Faria
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
AMPK
Extracellular matrix accumulation
Mesangial cells
NOX4
Phosphate
Transforming growth factor ß-1
Online Access:http://www.karger.com/Article/FullText/366336

Internet

http://www.karger.com/Article/FullText/366336

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