A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes

The atypical cadherins Fat and Dachsous (Ds) have been found to underlie planar cell polarity (PCP) in many tissues. Theoretical models suggest that polarity can arise from localized feedbacks on Fat-Ds complexes at the cell boundary. However, there is currently no direct evidence for the existence...

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Bibliographic Details
Main Authors: Olga Loza, Idse Heemskerk, Nadav Gordon-Bar, Liat Amir-Zilberstein, Yunmin Jung, David Sprinzak
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/24820