Tumor Cell-Secreted ISG15 Promotes Tumor Cell Migration and Immune Suppression by Inducing the Macrophage M2-Like Phenotype

Tumor Cell-Secreted ISG15 Promotes Tumor Cell Migration and Immune Suppression by Inducing the Macrophage M2-Like Phenotype

Interferon-stimulated gene 15 (ISG15) is known to be involved in tumor progression. We previously reported that ISG15 expressed on nasopharyngeal carcinoma (NPC) cells and related to poor prognosis of patients with NPC. We further observed that ISG15 can be secreted by NPC cell and expressed on the...

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Bibliographic Details
Main Authors: Ren-Hui Chen, Zhi-Wen Xiao, Xiao-Qing Yan, Ping Han, Fa-Ya Liang, Jing-Yi Wang, Shi-Tong Yu, Ting-Zhen Zhang, Si-Qi Chen, Qian Zhong, Xiao-Ming Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
interferon-stimulated gene 15
tumor-associated microenvironment (TAM)
nasopharyngeal carcinoma
tumor microenvironment (TME)
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.594775/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.594775/full

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