Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells
Innate lymphoid cells (ILCs) have been shown to be depleted during HIV-1 infection. Here the authors show that ILC loss is associated with CD4 depletion and gastrointestinal damage in a primate model of SIV infection.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05528-3 |
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doaj-88eb33c0a42b444ea1e49cf60a21484e2021-05-11T10:16:16ZengNature Publishing GroupNature Communications2041-17232018-09-019111210.1038/s41467-018-05528-3Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cellsJoseph C. Mudd0Kathleen Busman-Sahay1Sarah R. DiNapoli2Stephen Lai3Virginia Sheik4Andrea Lisco5Claire Deleage6Brian Richardson7David J. Palesch8Mirko Paiardini9Mark Cameron10Irini Sereti11R. Keith Reeves12Jacob D. Estes13Jason M. Brenchley14Barrier Immunity Section, Lab of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, IncBarrier Immunity Section, Lab of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthBarrier Immunity Section, Lab of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCenter for Drug Evaluation and Research, Food and Drug AdministrationClinical and Molecular Retrovirology Section/Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of HealthAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, IncDepartment of Epidemiology and Biostatistics, Case Western Reserve UniversityDivision of Microbiology and Immunology, Yerkes National Primate Research Center, Emory UniversityDivision of Microbiology and Immunology, Yerkes National Primate Research Center, Emory UniversityDepartment of Epidemiology and Biostatistics, Case Western Reserve UniversityClinical and Molecular Retrovirology Section/Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical SchoolAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, IncBarrier Immunity Section, Lab of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthInnate lymphoid cells (ILCs) have been shown to be depleted during HIV-1 infection. Here the authors show that ILC loss is associated with CD4 depletion and gastrointestinal damage in a primate model of SIV infection.https://doi.org/10.1038/s41467-018-05528-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Joseph C. Mudd Kathleen Busman-Sahay Sarah R. DiNapoli Stephen Lai Virginia Sheik Andrea Lisco Claire Deleage Brian Richardson David J. Palesch Mirko Paiardini Mark Cameron Irini Sereti R. Keith Reeves Jacob D. Estes Jason M. Brenchley |
| spellingShingle |
Joseph C. Mudd Kathleen Busman-Sahay Sarah R. DiNapoli Stephen Lai Virginia Sheik Andrea Lisco Claire Deleage Brian Richardson David J. Palesch Mirko Paiardini Mark Cameron Irini Sereti R. Keith Reeves Jacob D. Estes Jason M. Brenchley Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells Nature Communications |
| author_facet |
Joseph C. Mudd Kathleen Busman-Sahay Sarah R. DiNapoli Stephen Lai Virginia Sheik Andrea Lisco Claire Deleage Brian Richardson David J. Palesch Mirko Paiardini Mark Cameron Irini Sereti R. Keith Reeves Jacob D. Estes Jason M. Brenchley |
| author_sort |
Joseph C. Mudd |
| title |
Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells |
| title_short |
Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells |
| title_full |
Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells |
| title_fullStr |
Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells |
| title_full_unstemmed |
Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells |
| title_sort |
hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-09-01 |
| description |
Innate lymphoid cells (ILCs) have been shown to be depleted during HIV-1 infection. Here the authors show that ILC loss is associated with CD4 depletion and gastrointestinal damage in a primate model of SIV infection. |
| url |
https://doi.org/10.1038/s41467-018-05528-3 |
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