Foxp3+ regulatory T cells are required for recovery from severe sepsis.

Foxp3+ regulatory T cells are required for recovery from severe sepsis.

The role of regulatory T cells (Tregs) in bacterial sepsis remains controversial because antibody-mediated depletion experiments gave conflicting results. We employed DEREG mice (DEpletion of REGulatory T cells) and a caecal ligation and puncture model to elucidate the role of CD4(+)Foxp3(+) Tregs i...

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Bibliographic Details
Main Authors: Franziska Kühlhorn, Matthias Rath, Katrin Schmoeckel, Katharina Cziupka, Huu Hung Nguyen, Petra Hildebrandt, Thomas Hünig, Tim Sparwasser, Jochen Huehn, Christian Pötschke, Barbara M Bröker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3665556?pdf=render

Internet

http://europepmc.org/articles/PMC3665556?pdf=render

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